Aquarian
Reef pro
It would make me open my eyes and run!
First real salt water change. !!
- Thread starter Lesely
- Start date
mariobrothersleeve
squirrel
Where is bronson? He acts like he works or something. I've tried luring him in several posts.
salt_for_brains
Alabama Reefer
Exactly!!! Plus I am having knee surgery in the morning so that is going to put me out a few more weeks. Hopefully we will be dried out by then;)
mariobrothersleeve
squirrel
Lucky you, I'm going to have my 3rd back surgery in 2 weeks and some change. Golf from the hovercraft.
salt_for_brains
Alabama Reefer
He is probably in the bed b/c he is old:D
salt_for_brains
Alabama Reefer
Yeah, I'll take knee over back any day. Good luck and a speedy recovery to you my friend:)
mariobrothersleeve
squirrel
I agree. Injury was April 3 of last year. Got the disc trimmed, didn't work than fused and now I blew the disc above it. At least I can walk, knees don't look to much fun.... it's a bitch getting old.
Aquarian
Reef pro
He's researching Austin Powers
Aquarian
Reef pro
Well that putts my bald head and failing hearing in perspective.
Lesely
Reefing newb
I take it you have a generator for your tank ??
salt_for_brains
Alabama Reefer
Yes ma'am it is a necessity in this part of the country;)
Aquarian
Reef pro
It is here too, but for us it the winter storms when we need it.
mariobrothersleeve
squirrel
I would rather have a bad back. :-)
mariobrothersleeve
squirrel
I mean I WOULD RATHER HAVE A BAD BACK.
Aquarian
Reef pro
HUH?!?! Speak up Igor, I can't read your blowhole humpback!
Aquarian
Reef pro
One more thing they have down under
http://medicalxpress.com/news/2014-04-coral-reefs-potent-anti-hiv-proteins.html
Coral reefs provide potent new anti-HIV proteins
Researchers have discovered a new class of proteins capable of blocking the HIV virus from penetrating T-cells, raising hope that the proteins could be adapted for use in gels or sexual lubricants to provide a potent barrier against HIV infection.
The proteins, called cnidarins, were found in a feathery coral collected in waters off Australia's northern coast. Researchers zeroed in on the proteins after screening thousands of natural product extracts in a biorepository maintained by the National Cancer Institute. "It's always thrilling when you find a brand-new protein that nobody else has ever seen before," said senior investigator Barry O'Keefe, Ph.D., deputy chief of the Molecular Targets Laboratory at the National Cancer Institute's Center for Cancer Research. "And the fact that this protein appears to block HIV infection—and to do it in a completely new way—makes this truly exciting."
In the global fight against AIDS, there is a pressing need for anti-HIV microbicides that women can apply to block HIV infection without relying on a man's willingness to use a condom. Koreen Ramessar, Ph.D., a postdoctoral research fellow at the National Cancer Institute and a member of the research team, said cnidarins could be ideally suited for use in such a product because the proteins block HIV transmission without encouraging the virus to become resistant to other HIV drugs.
"When developing new drugs, we're always concerned about the possibility of undermining existing successful treatments by encouraging drug resistance in the virus," said O'Keefe. "But even if the virus became resistant to these proteins, it would likely still be sensitive to all of the therapeutic options that are currently available."
The research team identified and purified the cnidarin proteins, then tested their activity against laboratory strains of HIV. The proteins proved astonishingly potent, capable of blocking HIV at concentrations of a billionth of a gram by preventing the first step in HIV transmission, in which the virus must enter a type of immune cell known as the T-cell.
"We found that cnidarins bind to the virus and prevent it from fusing with the T-cell membrane," said Ramessar. "This is completely different from what we've seen with other proteins, so we think the cnidarin proteins have a unique mechanism of action."
The next step is to refine methods for generating cnidarins in larger quantities so the proteins can be tested further to identify potential side effects or activity against other viruses. "Making more of it is a big key," said O'Keefe. "You can't strip the Earth of this coral trying to harvest this protein, so our focus now is on finding ways to produce more of it so we can proceed with preclinical testing."
The scientists discovered cnidarins while screening for proteins, a largely understudied component of natural product extracts found in the National Cancer Institute's extract repository. The institute maintains a large collection of natural specimens gathered from around the world under agreements with their countries of origin. The specimens are available to researchers across the United States.
"The natural products extract repository is a national treasure," said O'Keefe. "You never know what you might find. Hopefully, discoveries like this will encourage more investigators to use this resource to identify extracts with activity against infectious disease."
Explore further: Geranium extracts inhibit HIV-1
More information: Koreen Ramessar will present the team's findings during the Experimental Biology 2014 meeting on Tuesday, April 29 from 12:15 – 1:45 p.m. at the Mode of Action Natural Products poster session in Exhibit Halls A-D (Poster #D208), San Diego Convention Center.
http://medicalxpress.com/news/2014-04-coral-reefs-potent-anti-hiv-proteins.html
Coral reefs provide potent new anti-HIV proteins
Researchers have discovered a new class of proteins capable of blocking the HIV virus from penetrating T-cells, raising hope that the proteins could be adapted for use in gels or sexual lubricants to provide a potent barrier against HIV infection.
The proteins, called cnidarins, were found in a feathery coral collected in waters off Australia's northern coast. Researchers zeroed in on the proteins after screening thousands of natural product extracts in a biorepository maintained by the National Cancer Institute. "It's always thrilling when you find a brand-new protein that nobody else has ever seen before," said senior investigator Barry O'Keefe, Ph.D., deputy chief of the Molecular Targets Laboratory at the National Cancer Institute's Center for Cancer Research. "And the fact that this protein appears to block HIV infection—and to do it in a completely new way—makes this truly exciting."
In the global fight against AIDS, there is a pressing need for anti-HIV microbicides that women can apply to block HIV infection without relying on a man's willingness to use a condom. Koreen Ramessar, Ph.D., a postdoctoral research fellow at the National Cancer Institute and a member of the research team, said cnidarins could be ideally suited for use in such a product because the proteins block HIV transmission without encouraging the virus to become resistant to other HIV drugs.
"When developing new drugs, we're always concerned about the possibility of undermining existing successful treatments by encouraging drug resistance in the virus," said O'Keefe. "But even if the virus became resistant to these proteins, it would likely still be sensitive to all of the therapeutic options that are currently available."
The research team identified and purified the cnidarin proteins, then tested their activity against laboratory strains of HIV. The proteins proved astonishingly potent, capable of blocking HIV at concentrations of a billionth of a gram by preventing the first step in HIV transmission, in which the virus must enter a type of immune cell known as the T-cell.
"We found that cnidarins bind to the virus and prevent it from fusing with the T-cell membrane," said Ramessar. "This is completely different from what we've seen with other proteins, so we think the cnidarin proteins have a unique mechanism of action."
The next step is to refine methods for generating cnidarins in larger quantities so the proteins can be tested further to identify potential side effects or activity against other viruses. "Making more of it is a big key," said O'Keefe. "You can't strip the Earth of this coral trying to harvest this protein, so our focus now is on finding ways to produce more of it so we can proceed with preclinical testing."
The scientists discovered cnidarins while screening for proteins, a largely understudied component of natural product extracts found in the National Cancer Institute's extract repository. The institute maintains a large collection of natural specimens gathered from around the world under agreements with their countries of origin. The specimens are available to researchers across the United States.
"The natural products extract repository is a national treasure," said O'Keefe. "You never know what you might find. Hopefully, discoveries like this will encourage more investigators to use this resource to identify extracts with activity against infectious disease."
Explore further: Geranium extracts inhibit HIV-1More information: Koreen Ramessar will present the team's findings during the Experimental Biology 2014 meeting on Tuesday, April 29 from 12:15 – 1:45 p.m. at the Mode of Action Natural Products poster session in Exhibit Halls A-D (Poster #D208), San Diego Convention Center.
bronson
Reefing newb
Yeah baby!
mariobrothersleeve
squirrel
Finally. 4 Frickin hours later....
bronson
Reefing newb
Ive been pretending i was at work:D
bronson
Reefing newb
lmao your older than me salt!
